ZDHHC7

Across TCGA cell cohorts, ZDHHC7 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZDHHC7-associated genes across cancer lineages are FAM153B, DEFA6, and RNASE9. Each is linked with ZDHHC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC7-to-partner and partner-to-ZDHHC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM153B grouped by ZDHHC7-low versus ZDHHC7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC7→partner) and Y-score (partner→ZDHHC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM153B →	+0.425	+2.841	<.001	.004	3	1
LUNG_NSCLC_LUAD	DEFA6 →	+0.157	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.015	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRAMEF19 →	+0.016	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.131	+5.228	.004	.005	3	1
LUNG_NSCLC_LUAD	OR4M2 →	+0.257	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FAM153B by ZDHHC7 expression — LARGE_INTESTINE

Explore this box plot interactively →