ZDHHC7

Across TCGA pan-cancer cohorts, ZDHHC7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZDHHC7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZDHHC7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZDHHC7 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

HNSC, COAD, and KIRP are the cancer types where ZDHHC7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZDHHC7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.622	<.001	11	view →
COAD	Female	II,III,IV	−0.504	<.001	10	view →
KIRP	All	IV	+1.127	.001	9	view →
THCA	Male	III,IV	−0.571	<.001	8	view →
LIHC	Female	All	+0.876	<.001	7	view →
READ	All	All	−0.542	<.001	7	view →
STAD	Male	II,III,IV	+0.915	<.001	6	view →
CHOL	Male	All	+2.791	<.001	5	view →
LUSC	All	II,III,IV	−0.494	<.001	5	view →
BRCA	Female	II,III,IV	−0.132	.034	4	view →
PAAD	All	All	+0.665	.034	2	view →
UCEC	All	All	−0.511	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZDHHC7–HNSC

Open the HNSC breakdown →