ZDHHC3

Across TCGA patient cohorts, ZDHHC3 mutation is significantly associated with the RNA expression of many other genes, with 3,074 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC3-associated genes across cancer lineages are RN7SL134P, FADS1, and VTI1A. Each is linked with ZDHHC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC3-to-partner and partner-to-ZDHHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by ZDHHC3-low versus ZDHHC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC3→partner) and Y-score (partner→ZDHHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.095	+2.236	.003	.001	3	2
UCEC	FADS1 →	+0.571	+2.016	.005	.005	3	2
UCEC	VTI1A →	+0.336	+2.413	.003	<.001	3	2
UCEC	TIAL1 →	+0.324	+3.740	.008	<.001	3	2
UCEC	BAG3 →	+0.486	+2.649	.005	.005	3	2
UCEC	BUB3 →	+0.487	+3.882	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,074 associations by consensus.

RN7SL134P by ZDHHC3 expression — UCEC

Explore this box plot interactively →