ZDHHC3

Across TCGA pan-cancer cohorts, ZDHHC3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZDHHC3 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ZDHHC3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZDHHC3 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCS show a favorable association.

ACC, COAD, and UCS are the cancer types where ZDHHC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.279	0.633	<.001	102	view →
COAD	OS	Median	III,IV	0.869	0.684	.001	81	view →
UCS	OS	Median	IV	0.732	0.224	.018	52	view →
KIRC	OS	Tertile	All	0.860	0.760	<.001	52	view →
LIHC	DFS	Median	All	0.469	0.614	<.001	43	view →
UVM	OS	Quartile	All	0.902	0.587	.006	42	view →
PAAD	DFS	Quartile	All	0.213	0.482	.004	32	view →
SCLC	DFS	Median	III,IV	0.696	0.368	.007	32	view →
LUSC	DFS	Quartile	III,IV	0.508	0.830	.005	26	view →
MESO	OS	Tertile	III,IV	0.431	0.662	.013	24	view →
ESCA	OS	Median	II,III,IV	0.376	1.000	.003	20	view →
LGG	OS	Tertile	All	0.807	0.965	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZDHHC3–ACC (DFS)

Open the ACC breakdown →