ZDHHC3

Across TCGA patient cohorts, ZDHHC3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC3-associated genes across cancer lineages are eIF4E, eEF2, and EGFR_pY1068. Each is linked with ZDHHC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC3-to-partner and partner-to-ZDHHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZDHHC3-low versus ZDHHC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC3→partner) and Y-score (partner→ZDHHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.215	+3.700	.007	.001	3	2
UCEC	eEF2 →	+0.315	+2.000	.021	.030	3	1
UCEC	EGFR_pY1068 →	-0.231	-1.678	.016	.023	3	1
UCEC	A-Raf_pS299 →	-0.148	-2.700	.001	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.107	-2.575	.025	.010	3	1
UCEC	GATA6 →	-0.130	-3.155	.031	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by ZDHHC3 expression — UCEC

Explore this box plot interactively →