ZDHHC22

Across TCGA patient cohorts, ZDHHC22 mutation is significantly associated with the RNA expression of many other genes, with 1,305 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC22-associated genes across cancer lineages are RNA5SP412, RNU6-425P, and CA15P2. Each is linked with ZDHHC22 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC22-to-partner and partner-to-ZDHHC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by ZDHHC22-low versus ZDHHC22-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC22→partner) and Y-score (partner→ZDHHC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP412 →	+0.168	+7.930	<.001	.008	3	2
BLCA	RNU6-425P →	+0.416	+5.588	<.001	.004	3	2
BRCA	CA15P2 →	+0.053	+5.122	.001	.008	3	1
UCEC	SENP3-EIF4A1 →	+0.134	+2.286	<.001	.005	3	1
UCEC	RDM1 →	+0.655	+2.906	<.001	.002	3	1
UCEC	IGLV2-8 →	+1.861	+3.332	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,305 associations by consensus.

RNA5SP412 by ZDHHC22 expression — LUAD

Explore this box plot interactively →