ZDHHC21

Across TCGA pan-cancer cohorts, ZDHHC21 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZDHHC21 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZDHHC21 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZDHHC21 expression acts as an unfavorable survival marker.

COAD, SKCM, and BLCA are the cancer types where ZDHHC21 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.168	0.799	.004	15	view →
SKCM	OS	Median	All	0.366	0.785	<.001	14	view →
BLCA	DFS	Median	III,IV	0.132	0.572	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZDHHC21–COAD (OS)

Open the COAD breakdown →