Across TCGA pan-cancer cohorts, ZDHHC20P3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of ZDHHC20P3’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where ZDHHC20P3 RNA is repressed in tumor relative to normal tissue. In most cancer types ZDHHC20P3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where ZDHHC20P3 tumor–normal differential expression is most reproducible.