ZDHHC20-IT1

Across TCGA pan-cancer cohorts, ZDHHC20-IT1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZDHHC20-IT1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZDHHC20-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZDHHC20-IT1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCS show a favorable association.

COAD, KIRC, and LUSC are the cancer types where ZDHHC20-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.273	0.566	.007	36	view →
KIRC	DFS	Median	All	0.754	0.857	.001	24	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	24	view →
KIRP	DFS	Median	IV	0.594	0.039	.006	24	view →
OV	OS	Tertile	IV	0.642	0.964	.004	20	view →
LUAD	DFS	Median	II,III,IV	0.618	0.801	.006	18	view →
LGG	DFS	Tertile	All	0.656	0.801	.002	17	view →
ACC	OS	Median	II,III,IV	0.268	0.776	<.001	15	view →
KICH	DFS	Median	III,IV	0.277	0.882	.005	14	view →
UCS	DFS	Tertile	IV	0.956	0.312	.024	12	view →
PRAD	DFS	Tertile	All	0.827	0.912	.018	10	view →
PAAD	DFS	Median	All	0.373	0.163	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZDHHC20-IT1–COAD (DFS)

Open the COAD breakdown →