ZDHHC15

Across TCGA patient cohorts, ZDHHC15 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC15-associated genes across cancer lineages are MEK1, Notch1, and 14-3-3_beta. Each is linked with ZDHHC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC15-to-partner and partner-to-ZDHHC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZDHHC15-low versus ZDHHC15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC15→partner) and Y-score (partner→ZDHHC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.335	+2.321	.012	.005	3	2
UCEC	Notch1 →	+0.183	+2.594	<.001	.006	3	2
UCEC	14-3-3_beta →	-0.078	-2.295	.035	.033	3	1
UCEC	MSH2 →	-0.320	-1.973	<.001	.029	3	1
UCEC	MSH6 →	-0.345	-1.807	.004	.024	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.385	-1.489	.019	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MEK1 by ZDHHC15 expression — UCEC

Explore this box plot interactively →