ZDHHC15

Across TCGA pan-cancer cohorts, ZDHHC15 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZDHHC15’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZDHHC15 RNA is repressed in tumor relative to normal tissue. In most cancer types ZDHHC15 is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where ZDHHC15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZDHHC15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.438	<.001	12	view →
HNSC	Male	All	−0.640	<.001	12	view →
KICH	Female	All	−1.186	<.001	11	view →
COAD	Male	II,III,IV	−0.511	<.001	11	view →
THCA	Male	II,III,IV	−0.677	<.001	10	view →
LUAD	All	II,III,IV	−0.598	<.001	9	view →
BLCA	Male	IV	−1.357	<.001	7	view →
LUSC	All	III,IV	−1.243	<.001	7	view →
UCEC	All	All	−1.263	<.001	6	view →
BRCA	All	All	−0.713	<.001	6	view →
KIRP	Male	All	−0.693	<.001	6	view →
STAD	All	All	−0.502	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZDHHC15–KIRC

Open the KIRC breakdown →