ZDHHC15

Across TCGA cell cohorts, ZDHHC15 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZDHHC15-associated genes across cancer lineages are MCHR2, MRGPRX4, and KRTAP12-3. Each is linked with ZDHHC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC15-to-partner and partner-to-ZDHHC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCHR2 grouped by ZDHHC15-low versus ZDHHC15-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC15→partner) and Y-score (partner→ZDHHC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MCHR2 →	+0.046	+5.539	<.001	.003	3	1
BLOOD_Leukemia	MRGPRX4 →	+0.012	+4.922	.003	.009	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.117	+5.539	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.043	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PABPC1L2A →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6M1 →	+0.058	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MCHR2 by ZDHHC15 expression — BLOOD_Leukemia

Explore this box plot interactively →