ZDHHC1

Across TCGA cell cohorts, ZDHHC1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZDHHC1-associated genes across cancer lineages are MT4, MSGN1, and OR2T8. Each is linked with ZDHHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC1-to-partner and partner-to-ZDHHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT4 grouped by ZDHHC1-low versus ZDHHC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC1→partner) and Y-score (partner→ZDHHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MT4 →	+1.895	+3.556	.005	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR2T8 →	+0.193	+3.693	<.001	.005	3	1
LARGE_INTESTINE	C10orf53 →	+0.016	+3.632	<.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.165	+3.766	<.001	.004	3	1
LARGE_INTESTINE	DAZ3 →	+0.013	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MT4 by ZDHHC1 expression — LARGE_INTESTINE

Explore this box plot interactively →