ZCCHC8

Across TCGA patient cohorts, ZCCHC8 mutation is significantly associated with the RNA expression of many other genes, with 2,117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC8-associated genes across cancer lineages are MIR6893, RNU6-222P, and RNU6ATAC30P. Each is linked with ZCCHC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZCCHC8-to-partner and partner-to-ZCCHC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6893 grouped by ZCCHC8-low versus ZCCHC8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC8→partner) and Y-score (partner→ZCCHC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6893 →	+0.524	+5.037	<.001	.009	3	3
UCEC	RNU6-222P →	+0.366	+1.861	<.001	.006	3	2
BRCA	RNU6ATAC30P →	+0.338	+4.646	<.001	<.001	3	2
BRCA	MTCYBP45 →	+0.070	+4.215	<.001	.009	3	2
HNSC	MIR6090 →	+0.529	+5.468	<.001	.002	3	2
LUAD	KRTAP20-1 →	+0.254	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,117 associations by consensus.

MIR6893 by ZCCHC8 expression — SKCM

Explore this box plot interactively →