ZCCHC8

Across TCGA pan-cancer cohorts, ZCCHC8 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ZCCHC8 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ZCCHC8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZCCHC8 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

ACC, LGG, and LIHC are the cancer types where ZCCHC8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.393	0.761	<.001	98	view →
LGG	DFS	Median	All	0.666	0.804	<.001	51	view →
LIHC	DFS	Tertile	All	0.435	0.605	.001	43	view →
KICH	OS	Tertile	All	0.666	1.000	.010	36	view →
BRCA	DFS	Quartile	III,IV	0.950	0.752	.001	36	view →
UCS	DFS	Tertile	IV	0.932	0.321	.024	36	view →
KIRP	DFS	Quartile	II,III,IV	0.307	0.698	.003	29	view →
SCLC	OS	Tertile	All	0.567	0.258	<.001	26	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.515	.008	22	view →
UVM	DFS	Quartile	III,IV	0.172	0.735	.007	21	view →
KIRC	DFS	Tertile	II,III,IV	0.370	0.596	.002	19	view →
SKCM	DFS	Median	IV	0.663	0.152	.022	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ZCCHC8–ACC (DFS)

Open the ACC breakdown →