ZCCHC8

Across TCGA patient cohorts, ZCCHC8 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC8-associated genes across cancer lineages are ATM, eEF2, and MEK1. Each is linked with ZCCHC8 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZCCHC8-to-partner and partner-to-ZCCHC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZCCHC8-low versus ZCCHC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC8→partner) and Y-score (partner→ZCCHC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.636	-2.087	<.001	.005	3	4
UCEC	eEF2 →	+0.310	+2.999	.023	.035	3	2
UCEC	MEK1 →	+0.515	+3.087	<.001	<.001	3	2
UCEC	PCNA →	+0.191	+1.678	.021	.023	3	2
UCEC	14-3-3_beta →	-0.094	-1.973	.014	.029	3	1
UCEC	EGFR_pY1068 →	-0.284	-3.321	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by ZCCHC8 expression — UCEC

Explore this box plot interactively →