ZCCHC8

Across TCGA cell cohorts, ZCCHC8 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZCCHC8-associated genes across cancer lineages are OR10R2, ZNF479, and OR2T6. Each is linked with ZCCHC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC8-to-partner and partner-to-ZCCHC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by ZCCHC8-low versus ZCCHC8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC8→partner) and Y-score (partner→ZCCHC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10R2 →	+1.214	+3.551	.004	.009	3	2
URINARY_TRACT	ZNF479 →	+0.047	+4.087	<.001	.009	3	1
URINARY_TRACT	OR2T6 →	+0.005	+4.087	<.001	.009	3	1
URINARY_TRACT	KRTAP2-1 →	+0.100	+4.087	<.001	.009	3	1
LARGE_INTESTINE	AVP →	+0.056	+3.632	<.001	.003	3	1
LARGE_INTESTINE	OR52H1 →	+0.025	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR10R2 by ZCCHC8 expression — BLOOD_Leukemia

Explore this box plot interactively →