ZCCHC24

Across TCGA cell cohorts, ZCCHC24 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,349 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZCCHC24-associated GO terms across cancer lineages are Positive regulation of cell-substrate junction organization, Regulation of focal adhesion assembly, and Regulation of cell-substrate junction assembly. Each is linked with ZCCHC24 in more than 13 cancer types. Because this analysis shows association rather than direction, both ZCCHC24-to-partner and partner-to-ZCCHC24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate junction organization grouped by ZCCHC24-low versus ZCCHC24-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC24→partner) and Y-score (partner→ZCCHC24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cell-substrate junction organization →	+0.197	+1.503	<.001	<.001	3	14
BONE	Regulation of focal adhesion assembly →	+0.193	+1.710	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction assembly →	+0.193	+1.710	<.001	<.001	3	14
BONE	Positive regulation of focal adhesion assembly →	+0.249	+1.720	<.001	<.001	3	13
OESOPHAGUS	COPII-coated vesicle cargo loading →	+0.135	+1.074	<.001	.005	3	13
BONE	Collagen fibril organization →	+0.387	+1.698	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,349 associations by consensus.

Positive regulation of cell-substrate junction organization by ZCCHC24 expression — BONE

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