ZCCHC24

Across TCGA pan-cancer cohorts, ZCCHC24 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ZCCHC24 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ZCCHC24 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZCCHC24 expression acts as an unfavorable survival marker, although some lineages such as LGG and BRCA show a favorable association.

BLCA, LGG, and BRCA are the cancer types where ZCCHC24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	II,III,IV	0.461	0.608	.003	55	view →
LGG	DFS	Median	All	0.824	0.643	<.001	54	view →
BRCA	OS	Tertile	III,IV	0.910	0.740	<.001	40	view →
UCS	DFS	Tertile	III,IV	0.563	0.191	.007	30	view →
OV	OS	Quartile	III,IV	0.287	0.413	.017	26	view →
SKCM	OS	Quartile	All	0.840	0.706	.003	25	view →
LUAD	OS	Quartile	II,III,IV	0.883	0.668	.003	20	view →
HNSC	DFS	Quartile	IV	0.415	0.191	.009	20	view →
MESO	OS	Median	IV	0.815	0.287	<.001	18	view →
KIRP	OS	Quartile	All	0.873	0.969	.006	18	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	17	view →
CESC	DFS	Median	All	0.677	0.800	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ZCCHC24–BLCA (DFS)

Open the BLCA breakdown →