ZCCHC24

Across TCGA cell cohorts, ZCCHC24 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZCCHC24-associated genes across cancer lineages are LMNTD1, OR4F5, and MAGEB1. Each is linked with ZCCHC24 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC24-to-partner and partner-to-ZCCHC24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMNTD1 grouped by ZCCHC24-low versus ZCCHC24-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC24→partner) and Y-score (partner→ZCCHC24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LMNTD1 →	+0.157	+3.969	<.001	.002	3	1
LARGE_INTESTINE	OR4F5 →	+0.024	+3.345	<.001	.007	3	1
LARGE_INTESTINE	MAGEB1 →	+0.193	+3.878	<.001	.003	3	1
LARGE_INTESTINE	TIFAB →	+0.004	+3.977	<.001	.001	3	1
LARGE_INTESTINE	ACTL7B →	+0.083	+3.766	<.001	.004	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

LMNTD1 by ZCCHC24 expression — LARGE_INTESTINE

Explore this box plot interactively →