ZCCHC18

Across TCGA pan-cancer cohorts, ZCCHC18 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZCCHC18 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZCCHC18 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZCCHC18 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LIHC, and STAD are the cancer types where ZCCHC18 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.473	.006	30	view →
LIHC	OS	Median	All	0.015	0.784	<.001	12	view →
STAD	DFS	Median	All	0.210	0.709	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZCCHC18–UCEC (DFS)

Open the UCEC breakdown →