ZCCHC18

Across TCGA pan-cancer cohorts, ZCCHC18 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZCCHC18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZCCHC18 RNA is repressed in tumor relative to normal tissue. In most cancer types ZCCHC18 is over-expressed in tumor, although a few such as KICH and READ show the opposite, repressed pattern.

KICH, HNSC, and LIHC are the cancer types where ZCCHC18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZCCHC18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.545	<.001	8	view →
HNSC	All	III,IV	+0.146	.006	5	view →
LIHC	Female	All	+0.106	.001	5	view →
CHOL	Male	All	+0.435	<.001	2	view →
KIRP	All	IV	+0.417	.013	2	view →
READ	All	All	−0.332	.016	2	view →
PRAD	All	All	−0.296	<.001	2	view →
BRCA	All	All	−0.102	.042	2	view →
BLCA	Male	IV	−0.822	.001	1	view →
LUAD	Female	III,IV	−0.228	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZCCHC18–KICH

Open the KICH breakdown →