ZCCHC18

Across TCGA patient cohorts, ZCCHC18 mutation is significantly associated with the RNA expression of many other genes, with 4,025 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC18-associated genes across cancer lineages are RNA5SP412, RN7SKP257, and RNA5SP410. Each is linked with ZCCHC18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC18-to-partner and partner-to-ZCCHC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by ZCCHC18-low versus ZCCHC18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC18→partner) and Y-score (partner→ZCCHC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.495	+1.841	<.001	<.001	3	2
STAD	RN7SKP257 →	+0.157	+4.520	.008	.005	3	2
UCEC	RNA5SP410 →	+0.431	+1.850	<.001	<.001	3	2
UCEC	RNA5SP413 →	+0.767	+1.338	<.001	.009	3	2
UCEC	RNA5SP417 →	+0.331	+1.596	<.001	.008	3	2
UCEC	RNA5SP422 →	+0.573	+1.732	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,025 associations by consensus.

RNA5SP412 by ZCCHC18 expression — UCEC

Explore this box plot interactively →