ZCCHC18

Across TCGA cell cohorts, ZCCHC18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,250 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZCCHC18-associated GO terms across cancer lineages are DNA-templated transcription initiation, Positive regulation of action potential, and Regulation of cell cycle G1/S phase transition. Each is linked with ZCCHC18 in more than 10 cancer types. Because this analysis shows association rather than direction, both ZCCHC18-to-partner and partner-to-ZCCHC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by ZCCHC18-low versus ZCCHC18-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC18→partner) and Y-score (partner→ZCCHC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DNA-templated transcription initiation →	+0.068	+0.833	<.001	<.001	3	11
LUNG_SCLC	Positive regulation of action potential →	-0.921	-1.338	.002	.003	3	11
STOMACH	Regulation of cell cycle G1/S phase transition →	+0.072	+1.101	<.001	<.001	3	11
LUNG_SCLC	Heterochromatin formation →	+0.064	+1.322	.001	<.001	3	11
LUNG_SCLC	Host-mediated perturbation of viral transcription →	+0.097	+1.734	.006	<.001	3	11
LUNG_SCLC	Carboxylic acid transport →	-0.052	-1.304	.004	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,250 associations by consensus.

DNA-templated transcription initiation by ZCCHC18 expression — BREAST

Explore this box plot interactively →