ZCCHC18

Across TCGA cell cohorts, ZCCHC18 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZCCHC18-associated genes across cancer lineages are IFNA8, SCGB1C1, and MROH5. Each is linked with ZCCHC18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC18-to-partner and partner-to-ZCCHC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA8 grouped by ZCCHC18-low versus ZCCHC18-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC18→partner) and Y-score (partner→ZCCHC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFNA8 →	+0.034	+4.930	<.001	.008	3	1
SOFT_TISSUE	SCGB1C1 →	+0.073	+5.977	<.001	.001	3	1
SOFT_TISSUE	MROH5 →	+0.021	+4.930	<.001	.008	3	1
SOFT_TISSUE	IFNA14 →	+0.032	+5.369	<.001	.004	3	1
LARGE_INTESTINE	CCL18 →	+0.129	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

IFNA8 by ZCCHC18 expression — SOFT_TISSUE

Explore this box plot interactively →