ZCCHC18

Across TCGA cell cohorts, ZCCHC18 mutation is significantly associated with the mutation status of many other genes, with 1,218 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZCCHC18-associated genes across cancer lineages are HACE1, ZNF732, and SETD5. Each is linked with ZCCHC18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC18-to-partner and partner-to-ZCCHC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HACE1 grouped by ZCCHC18-low versus ZCCHC18-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC18→partner) and Y-score (partner→ZCCHC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HACE1 →	+4.857	+4.297	.009	.009	1	2
BREAST	ZNF732 →	+4.857	+4.297	.009	.009	1	2
LARGE_INTESTINE	SETD5 →	+3.087	+4.392	.005	.005	1	2
LARGE_INTESTINE	UGP2 →	+4.087	+5.044	.001	.001	1	2
LARGE_INTESTINE	ATOH1 →	+4.087	+5.044	.001	.001	1	2
LARGE_INTESTINE	NIPAL4 →	+2.865	+4.217	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,218 associations by consensus.

HACE1 by ZCCHC18 expression — BREAST

Explore this box plot interactively →