ZCCHC12

Across TCGA patient cohorts, ZCCHC12 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC12-associated genes across cancer lineages are TFRC, Tuberin, and ATM. Each is linked with ZCCHC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC12-to-partner and partner-to-ZCCHC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ZCCHC12-low versus ZCCHC12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC12→partner) and Y-score (partner→ZCCHC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.573	+1.925	.002	.005	3	2
UCEC	Tuberin →	+0.231	+2.321	.017	.033	3	2
UCEC	ATM →	-0.352	-1.584	.031	.019	3	2
UCEC	eIF4G →	+0.257	+1.584	.021	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.104	-1.896	.020	.015	3	1
UCEC	JNK_pT183_Y185 →	-0.147	-2.222	.015	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

TFRC by ZCCHC12 expression — UCEC

Explore this box plot interactively →