ZCCHC12

Across TCGA pan-cancer cohorts, ZCCHC12 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZCCHC12’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZCCHC12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZCCHC12 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

THCA, KICH, and UCEC are the cancer types where ZCCHC12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZCCHC12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	+6.725	<.001	10	view →
KICH	All	II,III,IV	−0.404	<.001	10	view →
UCEC	All	III,IV	−5.656	<.001	8	view →
COAD	All	II,III,IV	−0.494	<.001	6	view →
BRCA	Female	II,III,IV	−0.456	<.001	6	view →
HNSC	All	II,III,IV	+0.136	.005	6	view →
LIHC	All	All	+0.309	.002	5	view →
KIRC	Male	All	+0.110	.002	4	view →
READ	All	All	−0.882	.004	2	view →
CHOL	Male	All	+0.721	<.001	2	view →
PAAD	All	All	−0.542	.022	2	view →
PRAD	All	All	−0.435	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZCCHC12–THCA

Open the THCA breakdown →