ZCCHC12

Across TCGA cell cohorts, ZCCHC12 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,615 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZCCHC12-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, and mRNA splicing, via spliceosome. Each is linked with ZCCHC12 in more than 10 cancer types. Because this analysis shows association rather than direction, both ZCCHC12-to-partner and partner-to-ZCCHC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions grouped by ZCCHC12-low versus ZCCHC12-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC12→partner) and Y-score (partner→ZCCHC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNA splicing, via transesterification reactions →	+0.058	+1.207	.001	.006	3	11
LUNG_SCLC	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.058	+1.412	.001	.001	3	11
LUNG_SCLC	mRNA splicing, via spliceosome →	+0.058	+1.412	.001	.001	3	11
OVARY	Cytoplasmic translation →	+0.089	+0.302	<.001	.007	3	10
BONE	Protein-DNA complex organization →	+0.101	+2.388	<.001	<.001	3	10
LUNG_SCLC	Regulation of DNA-templated transcription elongation →	+0.085	+2.131	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,615 associations by consensus.

RNA splicing, via transesterification reactions by ZCCHC12 expression — LUNG_SCLC

Explore this box plot interactively →