ZCCHC12

Across TCGA cell cohorts, ZCCHC12 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZCCHC12-associated genes across cancer lineages are TBC1D3H, EPPIN, and NKX2-6. Each is linked with ZCCHC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC12-to-partner and partner-to-ZCCHC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3H grouped by ZCCHC12-low versus ZCCHC12-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC12→partner) and Y-score (partner→ZCCHC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TBC1D3H →	+0.486	+5.196	<.001	.005	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1
BLOOD_Leukemia	TEX43 →	+0.141	+5.969	<.001	.001	3	1
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

TBC1D3H by ZCCHC12 expression — OVARY

Explore this box plot interactively →