ZCCHC10

Across TCGA pan-cancer cohorts, ZCCHC10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZCCHC10 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZCCHC10 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZCCHC10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, GBM, and LSCC are the cancer types where ZCCHC10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.935	0.539	.006	25	view →
GBM	OS	Median	All	0.643	0.384	.002	21	view →
LSCC	OS	Median	III,IV	0.925	0.437	.014	4	view →
PDAC	OS	Median	III,IV	0.363	0.716	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZCCHC10–HNSC (OS)

Open the HNSC breakdown →