ZCCHC10

Across TCGA pan-cancer cohorts, ZCCHC10 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZCCHC10’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZCCHC10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZCCHC10 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, KIRC, and THCA are the cancer types where ZCCHC10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZCCHC10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	III,IV	+0.859	<.001	9	view →
KIRC	Male	All	+0.450	<.001	9	view →
THCA	Female	All	−0.392	<.001	9	view →
KICH	Female	All	−1.044	<.001	8	view →
BRCA	All	III,IV	+0.562	<.001	6	view →
HNSC	All	III,IV	+0.388	.002	6	view →
CHOL	All	All	+1.310	<.001	5	view →
LUSC	Female	All	−0.397	.011	5	view →
STAD	Female	All	+0.555	.008	4	view →
COAD	All	All	−0.437	.001	4	view →
KIRP	Male	II,III,IV	+0.458	.016	3	view →
LUAD	Female	III,IV	−0.443	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZCCHC10–LIHC

Open the LIHC breakdown →