ZCCHC10

Across TCGA patient cohorts, ZCCHC10 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC10-associated genes across cancer lineages are RNA5SP499, BPTFP1, and MIR4448. Each is linked with ZCCHC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC10-to-partner and partner-to-ZCCHC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP499 grouped by ZCCHC10-low versus ZCCHC10-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC10→partner) and Y-score (partner→ZCCHC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	RNA5SP499 →	+0.238	+7.962	<.001	.007	3	1
UCEC	BPTFP1 →	+0.182	+5.206	<.001	<.001	3	1
UCEC	MIR4448 →	+0.335	+4.352	.001	.008	3	1
UCEC	NUDT4P2 →	+0.106	+5.069	<.001	<.001	3	1
UCEC	RNA5SP414 →	+0.918	+3.840	<.001	.007	3	1
UCEC	RNA5SP411 →	+2.649	+4.393	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

RNA5SP499 by ZCCHC10 expression — THCA

Explore this box plot interactively →