ZCCHC10

Across TCGA cell cohorts, ZCCHC10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,598 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZCCHC10-associated GO terms across cancer lineages are Positive regulation of G2/MI transition of meiotic cell cycle, Attachment of spindle microtubules to kinetochore, and Dihydrofolate metabolic process. Each is linked with ZCCHC10 in more than 12 cancer types. Because this analysis shows association rather than direction, both ZCCHC10-to-partner and partner-to-ZCCHC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of G2/MI transition of meiotic cell cycle grouped by ZCCHC10-low versus ZCCHC10-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC10→partner) and Y-score (partner→ZCCHC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of G2/MI transition of meiotic cell cycle →	+0.142	+0.736	<.001	<.001	3	13
BONE	Attachment of spindle microtubules to kinetochore →	+0.183	+0.714	.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Dihydrofolate metabolic process →	+0.235	+0.911	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of centriole replication →	+0.132	+1.026	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Mitotic sister chromatid cohesion →	+0.149	+1.035	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.142	+0.965	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,598 associations by consensus.

Positive regulation of G2/MI transition of meiotic cell cycle by ZCCHC10 expression — PANCREAS

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