ZCCHC10

Across TCGA cell cohorts, ZCCHC10 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZCCHC10-associated genes across cancer lineages are CLPSL1, PRAMEF20, and ADAM7. Each is linked with ZCCHC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC10-to-partner and partner-to-ZCCHC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPSL1 grouped by ZCCHC10-low versus ZCCHC10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC10→partner) and Y-score (partner→ZCCHC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLPSL1 →	+0.158	+4.054	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ADAM7 →	+0.005	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CLPSL1 by ZCCHC10 expression — LARGE_INTESTINE

Explore this box plot interactively →