ZC4H2

Across TCGA patient cohorts, ZC4H2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC4H2-associated genes across cancer lineages are eEF2, 14-3-3_epsilon, and Annexin-1. Each is linked with ZC4H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC4H2-to-partner and partner-to-ZC4H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZC4H2-low versus ZC4H2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC4H2→partner) and Y-score (partner→ZC4H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.386	+3.807	.001	<.001	3	2
UCEC	14-3-3_epsilon →	+0.093	+1.392	.004	.019	3	2
UCEC	Annexin-1 →	+0.546	+2.926	.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.670	+1.341	<.001	.043	3	2
UCEC	Cyclin-B1 →	+0.730	+2.263	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.087	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eEF2 by ZC4H2 expression — UCEC

Explore this box plot interactively →