ZC4H2

Across TCGA pan-cancer cohorts, ZC4H2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZC4H2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZC4H2 RNA is repressed in tumor relative to normal tissue. In most cancer types ZC4H2 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and THCA are the cancer types where ZC4H2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC4H2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.839	<.001	9	view →
LUSC	Male	II,III,IV	−1.221	<.001	8	view →
THCA	Male	II,III,IV	−1.186	<.001	8	view →
KIRC	Male	II,III,IV	−0.542	<.001	7	view →
BRCA	All	All	−0.619	<.001	6	view →
LIHC	Female	III,IV	+0.811	.002	4	view →
LUAD	Female	III,IV	−0.756	.009	4	view →
CHOL	All	All	+1.585	<.001	3	view →
UCEC	All	All	−0.960	.003	2	view →
PRAD	All	All	−0.539	<.001	2	view →
BLCA	Male	IV	−1.485	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZC4H2–KICH

Open the KICH breakdown →