ZC4H2

Across TCGA cell cohorts, ZC4H2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,497 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZC4H2-associated GO terms across cancer lineages are Positive regulation of organelle assembly, Negative regulation of maintenance of sister chromatid cohesion, and Negative regulation of maintenance of mitotic sister chromatid cohesion. Each is linked with ZC4H2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ZC4H2-to-partner and partner-to-ZC4H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of organelle assembly grouped by ZC4H2-low versus ZC4H2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC4H2→partner) and Y-score (partner→ZC4H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.055	+1.166	<.001	.002	3	8
LUNG_NSCLC_LUSC	Negative regulation of maintenance of sister chromatid cohesion →	+0.109	+1.545	.008	.003	3	8
LUNG_NSCLC_LUSC	Negative regulation of maintenance of mitotic sister chromatid cohesion →	+0.109	+1.545	.008	.003	3	8
BLOOD_Lymphoma	Positive regulation of double-strand break repair via homologous recombination →	+0.055	+1.676	<.001	<.001	3	8
BLOOD_Leukemia	Regulation of cytoplasmic translational initiation →	+0.092	+1.599	<.001	<.001	3	7
BLOOD_Leukemia	Negative regulation of transcription by RNA polymerase I →	+0.111	+1.893	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,497 associations by consensus.

Positive regulation of organelle assembly by ZC4H2 expression — BLOOD_Myeloma

Explore this box plot interactively →