ZC3HAV1L

Across TCGA pan-cancer cohorts, ZC3HAV1L RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZC3HAV1L data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ZC3HAV1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZC3HAV1L expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

CESC, ACC, and MESO are the cancer types where ZC3HAV1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.634	0.845	<.001	98	view →
ACC	DFS	Median	All	0.393	0.764	<.001	94	view →
MESO	OS	Quartile	III,IV	0.414	0.722	.001	84	view →
KIRP	DFS	Tertile	All	0.607	0.771	.006	66	view →
LGG	OS	Median	All	0.747	0.871	<.001	52	view →
BLCA	DFS	Median	All	0.481	0.689	.002	51	view →
UCS	OS	Quartile	II,III,IV	0.617	0.210	.003	48	view →
KIRC	DFS	Quartile	All	0.913	0.690	<.001	42	view →
PAAD	OS	Tertile	All	0.331	0.616	.004	39	view →
SARC	OS	Tertile	All	0.428	0.756	.001	21	view →
KICH	OS	Median	III,IV	0.357	0.907	.006	21	view →
UVM	OS	Tertile	III,IV	0.347	0.915	.006	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZC3HAV1L–CESC (DFS)

Open the CESC breakdown →