ZC3HAV1L

Across TCGA pan-cancer cohorts, ZC3HAV1L RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZC3HAV1L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZC3HAV1L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZC3HAV1L is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where ZC3HAV1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3HAV1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+2.385	<.001	12	view →
KIRC	Male	All	+1.137	<.001	12	view →
LUAD	Male	III,IV	+2.131	<.001	11	view →
KIRP	All	IV	+1.965	<.001	11	view →
HNSC	Male	II,III,IV	+1.081	<.001	11	view →
BLCA	All	All	+1.432	<.001	9	view →
LUSC	Male	II,III,IV	+2.012	<.001	8	view →
KICH	Female	All	−1.962	<.001	8	view →
READ	All	II,III,IV	+1.967	<.001	7	view →
THCA	Male	All	−0.810	<.001	7	view →
CHOL	Male	All	+3.005	<.001	5	view →
STAD	Male	II,III,IV	+1.087	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZC3HAV1L–COAD

Open the COAD breakdown →