ZC3HAV1L

Across TCGA pan-cancer cohorts, ZC3HAV1L mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZC3HAV1L data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZC3HAV1L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZC3HAV1L expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, UCEC, and HNSC are the cancer types where ZC3HAV1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.965	0.722	.004	23	view →
UCEC	OS	Quartile	II,III,IV	0.366	1.000	.010	16	view →
HNSC	OS	Median	All	0.449	1.000	.023	15	view →
CCRCC	OS	Median	All	0.602	0.987	.005	9	view →
LSCC	DFS	Tertile	II,III,IV	0.892	0.556	.018	5	view →
PDAC	DFS	Quartile	All	0.707	0.906	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZC3HAV1L–LUAD (DFS)

Open the LUAD breakdown →