ZC3HAV1L

Across TCGA pan-cancer cohorts, ZC3HAV1L mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZC3HAV1L’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ZC3HAV1L mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZC3HAV1L is over-expressed in tumor.

CCRCC, LUAD, and LSCC are the cancer types where ZC3HAV1L tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3HAV1L mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.933	<.001	12	view →
LUAD	All	III,IV	+0.416	<.001	9	view →
LSCC	Male	II,III,IV	+0.459	<.001	6	view →
PDAC	All	All	+0.364	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZC3HAV1L–CCRCC

Open the CCRCC breakdown →