ZC3H8

Across TCGA patient cohorts, ZC3H8 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H8-associated genes across cancer lineages are Ku80, N-Ras, and p62 Lck ligand. Each is linked with ZC3H8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H8-to-partner and partner-to-ZC3H8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ZC3H8-low versus ZC3H8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H8→partner) and Y-score (partner→ZC3H8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.397	+3.183	.002	.010	3	1
UCEC	N-Ras →	-0.229	-3.156	<.001	.020	3	1
UCEC	p62 Lck ligand →	+0.525	+3.179	.003	.010	3	1
UCEC	Tuberin →	+0.354	+2.817	.016	.036	3	1
UCEC	C-Raf →	+0.290	+3.000	<.001	.036	3	1
UCEC	beta-Catenin →	+0.739	+3.169	.007	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by ZC3H8 expression — UCEC

Explore this box plot interactively →