ZC3H8

Across TCGA pan-cancer cohorts, ZC3H8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZC3H8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZC3H8 RNA is repressed in tumor relative to normal tissue. In most cancer types ZC3H8 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, COAD, and BLCA are the cancer types where ZC3H8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.824	<.001	11	view →
COAD	Male	IV	+1.200	<.001	10	view →
BLCA	All	All	+0.761	<.001	9	view →
LIHC	Female	II,III,IV	+0.843	<.001	8	view →
LUAD	Male	All	+0.583	<.001	8	view →
HNSC	All	III,IV	+0.472	.002	8	view →
READ	All	All	+1.257	<.001	7	view →
LUSC	Male	II,III,IV	+1.251	<.001	7	view →
CHOL	All	All	+1.701	<.001	5	view →
STAD	All	II,III,IV	+0.652	<.001	4	view →
KIRP	All	IV	+0.772	.021	3	view →
KICH	Female	All	−0.669	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZC3H8–THCA

Open the THCA breakdown →