ZC3H8

Across TCGA cell cohorts, ZC3H8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,109 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZC3H8-associated GO terms across cancer lineages are Positive regulation of telomerase RNA localization to Cajal body, Epigenetic regulation of gene expression, and Regulation of DNA repair. Each is linked with ZC3H8 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZC3H8-to-partner and partner-to-ZC3H8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of telomerase RNA localization to Cajal body grouped by ZC3H8-low versus ZC3H8-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H8→partner) and Y-score (partner→ZC3H8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of telomerase RNA localization to Cajal body →	+0.107	+0.623	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.076	+1.008	<.001	.001	3	15
BONE	Regulation of DNA repair →	+0.063	+0.896	.007	.001	3	15
BONE	Subtelomeric heterochromatin formation →	+0.108	+0.725	<.001	<.001	3	14
BONE	Metaphase/anaphase transition of cell cycle →	+0.135	+0.557	.003	.008	3	14
CNS	tRNA modification →	+0.042	+0.522	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,109 associations by consensus.

Positive regulation of telomerase RNA localization to Cajal body by ZC3H8 expression — LUNG_SCLC

Explore this box plot interactively →