ZC3H7B

Across TCGA patient cohorts, ZC3H7B mutation is significantly associated with the RNA expression of many other genes, with 4,409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H7B-associated genes across cancer lineages are PPM1D, TVP23B, and C18orf32. Each is linked with ZC3H7B in more than 3 cancer types. Because this analysis shows association rather than direction, both ZC3H7B-to-partner and partner-to-ZC3H7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPM1D grouped by ZC3H7B-low versus ZC3H7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H7B→partner) and Y-score (partner→ZC3H7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPM1D →	+0.280	+1.593	.009	.005	3	4
COAD	TVP23B →	+0.629	+3.472	<.001	.002	3	3
UCEC	C18orf32 →	+0.391	+2.656	<.001	<.001	3	3
UCEC	ERCC8 →	+0.326	+2.401	<.001	<.001	3	3
UCEC	PTCD2 →	+0.299	+2.031	<.001	.001	3	3
COAD	LYG1 →	+0.691	+3.553	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,409 associations by consensus.

PPM1D by ZC3H7B expression — UCEC

Explore this box plot interactively →