ZC3H7B

Across TCGA pan-cancer cohorts, ZC3H7B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZC3H7B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZC3H7B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZC3H7B is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where ZC3H7B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H7B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.812	<.001	11	view →
THCA	All	III,IV	−0.755	<.001	9	view →
LIHC	All	All	+0.651	<.001	7	view →
COAD	All	All	+0.391	<.001	7	view →
STAD	Male	II,III,IV	+1.064	<.001	6	view →
KIRP	Male	All	−0.757	<.001	6	view →
KIRC	Male	II,III,IV	−0.623	<.001	6	view →
BRCA	Female	II,III,IV	−0.477	<.001	6	view →
CHOL	Male	All	+1.758	<.001	5	view →
LUAD	All	All	−0.333	<.001	5	view →
UCEC	All	All	−0.791	<.001	4	view →
KICH	All	All	−0.414	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZC3H7B–HNSC

Open the HNSC breakdown →