ZC3H7B

Across TCGA cell cohorts, ZC3H7B mutation is significantly associated with the RNA expression of many other genes, with 401 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H7B-associated genes across cancer lineages are OR2L8, EDEM1, and TMED2. Each is linked with ZC3H7B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H7B-to-partner and partner-to-ZC3H7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by ZC3H7B-low versus ZC3H7B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H7B→partner) and Y-score (partner→ZC3H7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2L8 →	+0.038	+4.450	<.001	.004	3	2
BLOOD_Leukemia	EDEM1 →	+1.295	+3.199	.001	.007	3	2
LARGE_INTESTINE	TMED2 →	+0.493	+3.169	.001	.005	3	2
LARGE_INTESTINE	ALG6 →	+0.660	+3.588	<.001	<.001	3	2
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
OVARY	OR2M4 →	+0.070	+4.700	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 401 associations by consensus.

OR2L8 by ZC3H7B expression — OVARY

Explore this box plot interactively →