ZC3H7A

Across TCGA pan-cancer cohorts, ZC3H7A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZC3H7A data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZC3H7A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZC3H7A expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where ZC3H7A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.537	0.922	.006	13	view →
HNSC	OS	Quartile	All	0.337	1.000	.017	12	view →
LUAD	OS	Quartile	III,IV	1.000	0.298	.020	8	view →
LSCC	DFS	Quartile	II,III,IV	0.436	0.823	.024	8	view →
PDAC	OS	Quartile	All	0.616	0.290	.009	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZC3H7A–CCRCC (DFS)

Open the CCRCC breakdown →