ZC3H7A

Across TCGA pan-cancer cohorts, ZC3H7A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZC3H7A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZC3H7A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZC3H7A is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where ZC3H7A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H7A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.027	<.001	11	view →
KIRC	Female	All	+0.531	<.001	11	view →
THCA	Male	III,IV	−1.021	<.001	10	view →
LUSC	All	III,IV	−0.848	<.001	8	view →
LIHC	Female	All	+0.641	<.001	7	view →
KICH	Female	All	−0.973	<.001	6	view →
CHOL	Male	All	+1.689	<.001	5	view →
LUAD	All	All	−0.210	.023	3	view →
BLCA	Male	IV	−0.724	.003	2	view →
UCEC	All	All	−0.673	<.001	2	view →
COAD	Male	All	+0.208	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZC3H7A–HNSC

Open the HNSC breakdown →